MTSS1 - candidate metastasis suppressor gene.doc

 PAGE \* MERGEFORMAT 16 MTSS1 - candidate metastasis suppressor gene [Keywords:] MTSS1, MIM / MIM B, tumor metastasis, inhibiting gene, cytoskeleton, literature review Cancer is the number one killer of harm to human health. Cancer is a major threat to human life and health disease, the incidence occult, high mortality, but there is no effective way to completely cure. Invasion and metastasis are the salient features of malignant tumors, tumor off from the original tumor cells invade surrounding tissues to distant metastasis, is a clinical anti-tumor treatment failure and the leading cause of death in patients, so the invasion and metastasis of malignant tumors become the key to cancer research. Invasion and metastasis of cancer cells is extremely complex and can be broadly summarized as the following process: angiogenesis cancer cells shed from the primary tumor and the extracellular matrix, adhesion and basement membrane degradation occurs through the vessel wall into the circulation and reach distant parts of the following made part of the formation of metastatic lesions continued proliferation [1]. metastasis suppressor gene (tumor metastasis suppressor gene is inhibited spontaneous and tumor metastasis in general can be seen on the no effect on primary tumor growth of a class of genes, often in the metastatic lesion transcription through methylation or post-translational modifications and a series of mechanisms to express reduced performance. tumor suppressor gene mutations, the inhibition of tumor metastasis in the same time can also affect the growth of primary tumor. At present, only nm23, KAI1, KISS1, MKK4 , BrMS1 meet the definition of standards, which is the most clear, and KAI1 E. nm23 certain genes in animal models to inhibit tumor metastasis, but whether it will affect the growth of the primary tumor is still unclear, these genes, including prostate cancer SseCK gene melanoma gelsolin, CD9, CD63 gene and colon cancer CSK (c.terminal Sre k