Myelodysplastic syndrome and activated lymphocyte subsets in the analysis of.doc

 PAGE \* MERGEFORMAT 8 Myelodysplastic syndrome and activated lymphocyte subsets in the analysis of Author: Yang Jun, WANG Chun, Xie Kuangcheng, Yan-style may be, GAO Yan-rong, Qi Cai, Qin Ewing, Wan Li-ping, Yu Cai Abstract This study investigated the myelodysplastic syndrome (MDS) in patients with peripheral blood T cell subsets, B cells, NK cell numbers and activation status of clinical significance. By flow cytometry in 30 cases of MDS patients with peripheral blood T cells, B cells, NK cells and their surface activation molecules CD28, CD45RA, CD45RO, CD69, HLA-DR expression was detected and analyzed. 30 cases of MDS patients with low-risk group (RA RAS) 22 cases of high-risk group (RAEB RAEBT) 8 Li. The results showed that: MDS group of T cells (CD3 cells) of the percentage of normal control group, CD4 CD45RA cells (naive CD4 cells) values lower than the normal control group. MSD group of early activation of T cells (CD3 CD69 cells) and late-activated T cells (CD3 HLA-DR cells) values were significantly higher than the normal control group. Low-risk group (RA and RAS) mainly as a function of changes in T cell activation: early activation of T cells (CD3 CD69 cells) and late-activated T cells (CD3 HLA-DR cells) were significantly higher ratio, as well as reduction in the number of B cells. High-risk group (RAEB, and RAEBT) mainly for the T-cell subsets in the number of changes: CD3 cells, CD3 CD4 CD8-cells (T helper cells) reduction in the number, CD3 cells, HLA-DR and CD69 expression was not increased. Reduce the number of NK cells. Conclusion: MDS patients with the existence of T-cell number and function of the abnormal, and as the disease progresses changed, so T cell subsets and activation detection for judging the disease process and to guide treatment of great significance. Keywords: Myelodysplastic syndrome; T cell subsets; B cells; NK cells; activated signs Evaluation of the Subsets of Lymphocytes and Their Activated