Musk oolong pill anti-inflammatory and analgesic pharmacological studies.doc

 PAGE \* MERGEFORMAT 34 Musk oolong pill anti-inflammatory and analgesic pharmacological studies Author: Wang Zhiwen, Ai-Guo Zhang, Yuan Q, Zhao Wenyi, Lili, Jia Xiurong, Cheng Patriotic Keywords: oolong musk pill;,, pharmacological research;,, anti-inflammatory;, and analgesic Abstract: Objective of the musk oolong pill anti-inflammatory and analgesic pharmacological studies provide experimental basis for clinical application. Methods The mouse ear swelling of rat paw edema, adjuvant arthritis and granuloma inflammation model, to study its anti-inflammatory effect; using mouse writhing and hot-plate method, to observe its analgesic effect. The results of the mouse ear inflammation of rat paw edema, adjuvant arthritis, granuloma, etc. were significantly inhibited (P lt;0.01); could inhibit the inflammatory exudate and leukocyte chemotaxis, and can significantly reduce the acetic acid induced writhing times in mice and prolong time of occurrence and writhing in mice significantly increased hot-plate pain threshold (P lt;0.01). Conclusion musk pill Oolong obvious anti-inflammatory and analgesic effect. Keywords:: musk oolong pill; pharmacological studies; anti-inflammatory; analgesic Abstract: ObjectiveTo study the anti-inflammatory and analgesic effects of Musk-Aconite-Earthworm Pill (MAEP) to provide an experimental foundation for clinical application.MethodsThe anti-inflammatory effect was determined with the models of the swelling of mouse ear, the rat carrageenin paw edema, adjuvant arthritis and the cotton ball like granuloma of mouse. The analgesic effect was determined with mouse writhing test and the hot plate test.ResultsThe MAEP could lessen the oedema of mouse’s ears and toes, decrease swelling of joints, inhibit inflammatory disease and the granuloma hyperplasia (P lt;0.01). It could depress inflammatory exudates and leukocyte chemotaxis, reduce the writhing times causing by glacial acetic acid, decrease mouse threshold