Naloxone in the use of cephalosporins caused by drinking during the wake disulfide reactions.doc

 PAGE \* MERGEFORMAT 5 Naloxone in the use of cephalosporins caused by drinking during the wake disulfide reactions [Keywords:] naloxone, cephalosporins, disulfide wake up response Naloxone (Naloxone, also known as allyl Oxymorphone for the opioid receptor antagonist, for the first time since 1960, has been successfully synthesized, not because of their pharmacological effects on normal, safety, large, significant effect, and therefore clinical more and more widely on the application. This statistic was admitted to our hospital emergency department during the use of cephalosporins disulfide wake up drinking response caused the 60 patients, and in which the application of naloxone. 1 Clinical data 1.1 General Information July 2006 -2008 in July were treated in the emergency department of our hospital 60 patients were treated with cephalosporin antibiotics drinking alcohol during the reaction led to disulfide awake patients, 48 #8203;#8203;male and 12 females, age maximum 65 and the youngest 20 years old. including the use of 26 patients cefoperazone, ceftriaxone in 20 cases, 10 cases of cefotaxime, cefuroxime 4 cases. 1.2 All patients showed clinical manifestations of fever for the face, head and neck vessels severe beating, chest tightness, tachycardia, irritability, etc.; In addition, there are 15 cases of nausea and vomiting in 10 cases, 5 cases of chest pain, respiratory depression in 1. Treatment of saline 250ml + 1.3 0.8 ~ 2.0mg intravenous naloxone, 10% glucose 400ml +10% potassium chloride 1.5g + Vit C 3.0g +50% glucose 100ml Continued points, and tachycardia were given propranolol (10mg orally, nausea, vomiting stomach complex to give amine (10mg intramuscular injection, and so measures to symptomatic treatment. 2 Results All patients had intravenous naloxone in the clinical symptoms resolved after about 0.5h and about 2h vast majority of patients return to normal, only in recent 4h individual patients returned to normal. Link