NAP activity in the joint HsCRP detection of blood in the differential diagnosis of fever of hematological malignancies clinical application of.doc

 PAGE \* MERGEFORMAT 7 NAP activity in the joint HsCRP detection of blood in the differential diagnosis of fever of hematological malignancies clinical application of [Abstract] Objective To investigate the detection of blood NAP activity in the joint HsCRP identify causes of fever in malignant hematologic diseases in the clinical application. Methods undergraduate hospitalized the past two years 300 cases of fever in patients with hematologic malignancies associated with analysis of pathogenic micro-organisms have eventually been confirmed 28 cases of fungal infections, bacterial infection in 160 cases, 47 cases of mixed infection, non-infection in 65 cases (non-pathogenic micro-organisms evidence that antibiotic treatment ineffective, and provide them with hormones, as well as effective treatment of the original disease). Fever in all patients routinely NAP activity in the blood of a joint HsCRP analyzed retrospectively. The results of fungal infections in patients with blood NAP median 165 points, the positive rate of 82%, HsCRP level of 12mg/dl, and the bacterial infection group, the mixed infection group, the non-infection group, the blood of patients with a median NAP points were 126,147 , 36, the positive rates were 68%, 76%, 32%, HsCRP levels were 11.6mg/dl, 10.8mg/dl, 0.8mg/dl. Patients with hematologic malignancies, or bacterial or fungal infection in patients with mixed-blood NAP activity and HsCRP were significantly higher than those of non-infected patients, the difference was statistically significant compared with each other; in patients who co-infection, fungal infections in patients with NAP activity than bacteria more pronounced increase in infected patients, mixed infection between them and compare the differences were statistically significant; HsCRP slightly higher in patients with fungal infections, but the difference was not statistically significant compared with each other. NAP activity in serum contribute to the joint detection of hem