Near infrared spectrum correlation method to add traditional Chinese medicine capsules sildenafil citrate.doc

 PAGE \* MERGEFORMAT 11 Near infrared spectrum correlation method to add traditional Chinese medicine capsules sildenafil citrate [Abstract] The near infrared spectrum of traditional Chinese medicine capsule correlation coefficient is added with rapid qualitative analysis of sildenafil citrate. Were used near infrared spectroscopy and fiber optic integrating sphere attachment measured spectrum to the West in citrate That non-chemical reference substance by near infrared spectroscopy as a reference spectrum, select a specific spectrum, according to sildenafil citrate was mixed with capsules to establish the minimum effective concentration from the sample spectrum and reference spectra in the spectral similarity coefficient threshold, the sample to determine whether it contains qualitative sildenafil citrate. Integrating Sphere Method: 6070 ~ 5800 cm-1 and 4170 ~ 4070 cm-1 spectrum, the threshold value of 70%, with 79 containing The commercially available sildenafil citrate samples to validate this method, the correlation coefficient greater than 70% of 72, accounting for 91.14% of the total sample, optical methods: selected 6070 ~ 5800 cm-1 spectrum for the characteristic spectrum section, set the threshold value of 65%, with 247 commercially available samples containing sildenafil citrate to verify a correlation coefficient of greater than 65% of 216, accounting for 87.45% of total samples. Experimental results show this method has better predictive power, as the market adds to the kinds of illegal drugs quickly and efficiently check means. [Keywords:] near-infrared diffuse reflectance spectroscopy, correlation coefficient method, qualitative analysis, medicine illegally added, sildenafil citrate 1 Introduction Near Infrared (NIR spectroscopy as a simple, fast, does not damage the sample characteristics, analysis of the field has gradually become a hot technology, in recent years in the field of drug analysis is widely used [1, 3], and in the figh