Near Infrared Spectroscopy in Sal B-line quality control of purified Research.doc

 PAGE \* MERGEFORMAT 13 Near Infrared Spectroscopy in Sal B-line quality control of purified Research Of: Zhang Yanying, Zhang Jinwei, Zhang, Liu Yan [Abstract] Objective using near infrared spectroscopy (NIR technology and establish the content of Sal B detection model and achieve industrial-scale production and purification of Chinese medicine on-line quality control. Methods online gathering near infrared spectroscopy, Sal B, the same time HPLC, using partial least squares method and purification process of determination Sal B model. Results The band is the best model 9 815 ~ 5 430 cm-1, the correlation coefficient r = 0.977 6, adjusted mean square RMSEC = 4.02. predictive value and the true value of the average relative error lt;5%. Conclusions NIR technology allows purification of Sal B-line quality control. [Keywords:] near-infrared, high performance liquid chromatography, Sal B, line quality control, production scale China’s current control mode of production technology of Chinese medicine with little regard process changes in the composition and content, the basic experience is still stuck in the traditional control method, while off-line detection of products can not meet the needs of production line testing. To achieve the production process on-line real-time quality control is to ensure quality medicine, uniform key for achieving the modernization of traditional Chinese medicine production technology bottleneck. Near Infrared Spectroscopy (near infrared, NIR is a rapid development in recent years, a rapid analysis technique, it is of the tested samples composition and structure information indirectly reflected. NIR spectra of samples for easy operation and low cost, no complex sample preparation, in line with the requirements of online testing. As the stoichiometry and the development of computer technology, NIR technology in the agriculture and oil industry has been widely used [1,2] In 2002, the U.S. FDA to make this technology as a sta