Neo-adjuvant radiotherapy and chemotherapy in the clinical application of advanced esophageal cancer.doc

 PAGE \* MERGEFORMAT 10 Neo-adjuvant radiotherapy and chemotherapy in the clinical application of advanced esophageal cancer 【Abstract】 Objective To investigate the neo-adjuvant oral UFT (UFT) over the same period hyperfractionated radiotherapy for advanced esophageal cancer near, long-term efficacy. Preoperative clinical stage of stage Ⅱ, Ⅲ, no radiotherapy and chemotherapy, surgery contraindications 147 cases of esophageal cancer patients group. Study group 51 cases, preoperative oral UFT350mg / m 2 · d, for 2 weeks, at the same time hyperfractionated radiation therapy, each dose of 1.5Gy, 2 times a day, with a total dose of 30Gy, radiation therapy 2 to 4 weeks after the end of surgery. Control group, 96 cases, preoperative have not been. Two pairs of cases close to long-term results were compared. Outcomes research group, the control group of radical resection rate was 86.27%, 69.79%; Study Group tumor stage, postoperative local recurrence rate than the control group was significantly lower; operative time, blood loss, after the first 1 chest drainage, postoperative complications, no significant difference between the two groups. Study group in the 3,5-year survival rates were 53.25%, 36.87% in the control group 3,5-year survival rates were 43.49%, 25.37%. KM survival curve differences between the two groups had no significant (P = 0.1001), but the study group was compared with non-remission in patients with remission were significantly increased (P = 0.0206). Conclusion Over the same period of oral UFT hyperfractionated radiotherapy can reduce the tumor stage, local recurrence rate, and improve short-term effect; to the improvement of long-term survival is not yet clear, but the ease of patients received significantly improve long-term survival. Keywords: Esophageal cancer chemotherapy, external radiotherapy Neoadjuvant therapy application study of neoadjuvant chemoradiotherapyfor locallyadvancedesophageal carcinoma