Neurotrophic factor in the treatment of the role of spinal cord injury research progress.doc

 PAGE \* MERGEFORMAT 15 Neurotrophic factor in the treatment of the role of spinal cord injury research progress Study: Fruit Chan, Nan Liang, Zhang Jian, Luqiu Yang, Zhang, XU Yan [Abstract] Spinal Cord Injury (Spinal Cord Injury, SCI) in the treatment of the medical profession has been the research focus in recent years, neurotrophic factors (neurotrophic factors, NTFs) the discovery of spinal cord injury (Spinal Cord Injure, SCI) brings the treatment of new hope. This is widely used to present several neurotrophic factors were reviewed. [Keywords:] neurotrophic factor; spinal cord injury Neurotrophic factor (neurotrophic factors, NTFs) are a class of neuronal survival, growth has to maintain the role of polypeptide growth factors, originally derived from the venom extract, can effectively promote and maintain neuronal growth, survival, differentiation, and executive function role. neurotrophic factors including nerve growth factor members (Nerve growth factor-NGF), brain-derived neurotrophic factor (Brain-derived neurotrophic factors BDNF), neurotrophin Ⅲ (Neurotrophines-3 NT 3), neurotrophin IV (Neurotrophines-4 NT 4 / 5), glial cell line-derived neurotrophic factor (glial cell line-derived neurotrophic factor, GDNF), more than ten kinds of polypeptide growth factors. These polypeptide growth factors and nerve cells not only to growth, development, maintenance of differentiation and function is closely related to, but also in damaged neurons, can protect their survival and promote their growth, so the nerve tissue in spinal cord injury repair process plays an important role. 1, nerve growth factor Nerve growth factor (Nerve growth factor NGF) by Rita Levi-Montgalcin first discovered in 1952, was the first discovery of the biological nerve growth factor. NGF is the most thorough studies, with nutrition and promote neurite outgrowth of neurons double biology function of a nerve cell growth regulator. Recent studies have found that nerve re