Neurotrophic factor and its time to study the progress of brain damage inferred.docVIP

 PAGE \* MERGEFORMAT 17 Neurotrophic factor and its time to study the progress of brain damage inferred Of: Cheng Hongxia Liu Yuli often emblem on front Zhang Bin Qingquan [Keywords:] forensic science; nerve growth factors; brain damage Time of brain injury has been a forensic study inferred hotspot to injury and death can be identified before his death wound, estimated survival time after injury. In recent years molecular biology techniques with applications in forensic science, so that the time of brain injury made encouraging results, but has not yet been satisfactorily resolved. Brain injury time with a variety of indicators inferred from analysis to determine, so to find some damage after a good correlation of objective indicators is an important task of forensic medicine [1]. Nervous system after cerebral contusion in a series of secondary injury may affect the patient’s health. Study found that brain contusion cerebral cortex, hippocampus and thalamus and other parts of neurotrophic factors (neurotrophic factors, NTFs) the relative increase in the secretion of [2]. Domestic foreign scholars NTFs after brain injury study found that, whether it is ischemic or traumatic, will appear NTFs increased expression and the expression peak appeared, and this change has by immunohistochemistry and in situ hybridization confirmed [3]. It should be noted that the current research in this area stays in qualitative judgments, while the NTFs and brain damage and temporal changes of the quantitative detection of rarely reported. Some scholars by image analysis techniques and statistical analysis methods for quantitative research, but in this area, especially since many factors are involved when the injury, how to get the quantitative detection of specific targets to be studied further. 1 NGF and brain injury 50 NGF in the early 20th century by the Levi Montalcini sarcoma cells in mice found the first neurotrophic factor, often referred to as 7sNGF.NGF is