New diabetes gene SLC30A8 of Bioinformatics.doc

 PAGE \* MERGEFORMAT 11 New diabetes gene SLC30A8 of Bioinformatics [Abstract] the purpose of using bioinformatics diabetic gene structure and function of SLC30A8. Methods based on the human genome database using BioEdit, DNAMAN and other tools as well as SMART, TMHMM Server v.2.0, NetPhos2.0 Serve, 3djigsaw other line tool, the basic properties of protein analysis, three dimensional structure prediction and functional prediction. Results SLC30A8 gene encodes a protein is a transmembrane protein, zinc transporters have an important effect of ion. Conclusion SLC30A8 gene encodes a protein may regulate insulin secretion. [Keywords:] Bioinformatics; 2 diabetes; SLC30A8 [Abstract] Objective To investigate the structure and function of type 2 diabetes gene (SLC30A8) by bioinformatic methods. Methods Based on the human genome resource database, the programs of BioEdit, DANMAN and on line tools SMART, MHMM Server v. 2.0, NetPhos2 .0 Serve, 3djigsaw were used for the analysis of protein basic characters, 3D structure and function prediction. Results The protein of gene SLC30A8 encoding was a transmembrane protein, it was important to transport zinc. Conclusions Protein encoded by SLC30A8 gene probably regulates and controls insulin secretion. [Keywords:] Bioinformatics; Type 2 diabetes; SLC30A8 Many studies show that genetic factors in type 2 diabetes (T2DM) in the pathogenesis plays an important role (1,2), but Department of polygenic T2DM disease, research progress is very slow, until the 2005, whether by the candidate positional cloning gene approach or linkage method, only a very small number of T2DM susceptibility gene in some ethnic studies to be replicated, and they only slightly increase the risk of T2DM (3). almost 2 years and more, along with SNPS high-throughput testing technology and the emergence of genome-wide association (GWA) study tactics, T2DM genetics have made some breakthroughs, the United States and European research organizations,