New multi-acid compounds POM2 Toxicological Safety Evaluation.doc

 PAGE \* MERGEFORMAT 10 New multi-acid compounds POM2 Toxicological Safety Evaluation Of: Zhang, in the washing river, Juan, Li kitchen wing, Wu Wenjie, Li Jing [Abstract] Objective To evaluate the new multi-acid compounds (POM 2) the safety, security based on its applications in toxicology. Methods Based on the preclinical toxicology evaluation of new drug methods oral acute toxicity, genetic toxicity tests, rats 30d feeding test. Results The oral median lethal dose acute toxicity test for the 868.96mg/kg, are low toxic compound, mouse bone marrow micronucleus test, bone marrow chromosome aberration test and Ames test results were negative, 30d feeding study in rats no significant adverse effects, compared with the control group the growth of rats, blood routine, blood biochemistry and dirty body ratio and other indicators showed no significant difference. Conclusion POM 2 compounds with low toxicity, no obvious teratogenic and mutagenic effects, with in-depth research and development value. [Keywords:] new acid compounds POM 2, micronucleus test, bone marrow chromosome aberration test, Ames test, Toxicology Acid compounds are a class of metal clusters with Keggin structure of the compound, is also a class of polynuclear complexes [1]. Is a variety of RNA viruses have a strong inhibitory effect of non-nucleoside analogues, the antiviral effect is mainly reflected in the anti- HIV, influenza, SARS, HBV aspects [25]. We antiviral compounds in the acid based on the study, prepared from a strong new anti-HBV activity of acid compounds POM 2. This pre-clinical basis of drug toxicity Toxicological evaluation of their physical safety, the compounds provide the basis for further development and application. 1 Materials and methods 1.1 Samples POM 2 new multi-acid compounds from the Jilin University School of Public Health provided the necessary experiments with distilled water into a concentration. 1.2 Animals and bacteria Kunming mice of cl