Ning asthma spray agent compound Orthogonal experiment of the extraction process.doc

 PAGE \* MERGEFORMAT 7 Ning asthma spray agent compound Orthogonal experiment of the extraction process Author: Yan Haixia, Wang Yi-Qin, Wang Guangdong, Zhang Ning, Yao Di [Abstract] Objective To study the compound rather asthma spray agent optimum extraction condition. Methods The orthogonal design method to the active ingredient ephedrine, and the content of baicalin as an indicator of the extraction process were optimized. The optimum conditions the results of water eight times, soaked 60 min, boiling two times, the 1st 30 min, the 2nd 60 min. Conclusion extract the active ingredient in this process conditions, can guarantee the content of active ingredients. [Keywords:] compound rather breath fogging agent; orthogonal design; ephedrine; baicalin Abstract: ObjectiveTo establish the optimal extracting technology for the preparation of Compound Ningchuan aerosol inhalation.Methodsoptimal extracting technology was selected using the content of L-ephedrine and baicaline.ResultsThe optimal conditions were as follow: 1 hour’s soaking, the water quantity was 8 times as much as the drug quantity, the boining time was 30 and 60 min in each time.ConclusionProducts prepared following this process ensure the content of the L-ephedrine and baicaline. Keywords:: Compound Ningchuan aerosol inhalation; Orthogonal design; L-ephedrine; baicaline Ning asthma spray agent compound derived from the name of Shanghai Traditional Chinese Medicine the clinical experience of Professor Zhu Ruiqun side by Sunburn ephedra, Huang Qin, Tianzhu son, Elaeagnus leaves, composed of eight Chinese herbal medicines, with Xuanfei phlegm, relieving cough and asthma of the effects. For the optimal extraction process, the active ingredient ephedrine writer Fang, baicalin content of the indexes, with the L9 (34) orthogonal experiment. Are reported below. An instrument and reagent 1100 Serise high-performance liquid chromatography (Agilent, USA); ephedrine hydrochloride, baicalin reference subs