O139 cholera vaccine field trial and evaluation of population.doc

 PAGE \* MERGEFORMAT 15 O139 cholera vaccine field trial and evaluation of population [Abstract] Objective To understand the crowd O139 cholera vaccine field trial and its evaluation method. Methods of literature at home and abroad in recent years, access to the O139 cholera vaccine field trial types and test methods. The results in the main carried out volunteers inactivated vaccine (parenteral and oral), live attenuated vaccines (oral) test, have shown a certain degree of immune effect; study population was the main choice for adult groups and children’s groups, sample size should be is large enough; test a random, double-blind, placebo-controlled trial is to avoid bias arising from the condition. Conclusion oral vaccine WC / rBS and BenGal-15 has better prospects for the study, building on the various serotypes O1 group, O139 has a long-term protective effect of polyvalent vaccine is the future directions of research. [Keywords:] O139 cholera vaccine; field test; Evaluation A total of recorded human history, 7 cholera epidemic. Most recently in 1961 from Indonesia since the 20th century, 70 years extended to the African continent, to South America in 1991. It was reported that cases of cholera in 1994, the American continent, more than one million, nearly 1 million people died. It is estimated that each year the world’s 12 million people die of cholera [1]. However, from October 1992 start, a new serogroup (O139 or Bengal) was found, and caused widespread epidemic in South Asia. 1993 O139 into our country, mainly in the South China coastal area popular. Derivative of strain O139 is EITOr, but it there are new kinds of genetic information encoded in a unique lipopolysaccharide O polysaccharide antigens and more than one cyst, epidemiological data show that the previous right-O1 cholera has the immunity of the O139 Almost does not work [2]. Thus, in the global need for a effective vaccine against O139 infection. Based on the research-O1 cholera vaccines