Of Alzheimer APP transgenic mice model in the field of application of Chinese medicine_0.docVIP

 PAGE \* MERGEFORMAT 13 Of Alzheimer APP transgenic mice model in the field of application of Chinese medicine [Keywords:] Alzheimer’s disease, APP transgenic mice, animal models, in the field of medicine Alzheimer’s disease (Alzheimer’s Disease, AD), also known as senile dementia, is a common neurodegenerative disease. With the aging of our population, AD showed a rising incidence trend in old age has become a threatening the fourth largest cause of human life (second only to heart disease, cancer and stroke), become the face of Geriatrics most serious problems. Data shows that by 2050, China accounted for about 65 years old and above 35% of the total population, the elderly aged 80 and over about 22%, while the AD patients are expected to reach 25 million, will be the impact on family and social development is an important constraint [1]. As the pathogenesis of AD is very complex etiology So far not clear, but also the lack of effective treatment, therefore, actively study the pathogenesis of AD, development of effective drug prevention and treatment of today’s AD research field of age-related diseases is one important issue. AD transgenic mouse model of human AD research indicates that significant progress has been nearly 10 years as the Institute of human disease outstanding achievements made by one of the top ten for the pathogenesis of AD research and screening of new drugs provides an effective model system [2]. At present, AD transgenic mouse models including amyloid precursor protein (APP), tau, anti-nerve growth factor and other co-expression of multiple genes, including APP transgenic mice at home and abroad more recognized and widely used to study the most in-depth one of AD transgenic model for further application of AD prevention and treatment of Chinese medicine foundation. 1 APP transgenic mouse model of pathological features of Alzheimer AD animal models for AD research is extremely important part, has become in recent years, med