Of norepinephrine on morphine-addicted rats parafascicular electrical activity of pain-related neurons of.doc

 PAGE \* MERGEFORMAT 5 Of norepinephrine on morphine-addicted rats parafascicular electrical activity of pain-related neurons of Author: Guan Yan, the Kim Soo-Dong, Zhang Shu-Jie, LIU Gui-lian, XU Man-Ying [Abstract] Objective: Effects of norepinephrine on morphine-addicted rats parafascicular electrical activity of pain-related neurons. Methods: The string to stimulate the sciatic nerve stimulation on the right to noxious stimulation, using extracellular recording glass microelectrodes in rat parafascicular electrical activity of pain-related neurons. Results: norepinephrine in rats addicted to morphine parafascicular nucleus evoked discharge of pain-excitation neurons latencies, evoked discharge frequency to reduce, inhibit electrical activity of pain-excitation neurons. while pain inhibitory neurons inhibited shortened, evoked discharge frequency increased, the promotion of pain inhibitory neuronal activity. Conclusion: Inhibition of norepinephrine in rat parafascicular morphine pain-related neurons evoked discharge, with analgesic effect. [Keywords:] noradrenaline; morphine dependence; rats; parafascicular nucleus; pain-related neurons 0 Introduction In recent years, studies suggest that parafascicular nucleus (Pf) is the cortical modulation of pain the next major hub of the structure. 1973 Zhang Xiangtong and others found in the rat Pf memory in some of the exciting response to noxious stimulation from the pain sensitive neurons, known as pain-excitation neurons (PEN). 1976 Nian Sun Mingzhi such as found within the rat Pf, there are still played on the inhibitory response to noxious stimulation of neurons, called the pain inhibitory neurons (PIN), and the PEN and PIN between the two with the activity, a common pain modulation. pain syndrome is a common acute morphine withdrawal symptoms. is an extremely excruciating and painful withdrawal reactions, so far still no ideal treatment. in this room the previous work has been that norepinephrine signif