Of nuclear factor NF-κ B in the immune response and understanding of the role of apoptosis.doc

 PAGE \* MERGEFORMAT 2 Of nuclear factor NF-κ B in the immune response and understanding of the role of apoptosis Nuclear transcription factor NF-κ B was originally in the mouse mature B cells and granulocyte cell tumor was found and named for the Kappa light chain gene expression in the nucleus of the regulator, but found that the next Research continues to exist in a variety of cells. Even if the virus, such as giant-cell disease CMV, hepatitis B virus, HBV, human immunodeficiency virus HIV-1 and influenza virus can be strong and effective use of NF-κ B transcriptional function. Of NF-κ B research interest is primarily focused on the importance of biomedical considerable control of gene transcription can be induced and control of the. One of the NF-κ B and I-κ B in immune regulation and disease occurrence and development of the role of particular concern. NF-κ B family structure and general function of NF-κ B is a dimer composed of two monomers transcription factor family, the prototype of its monomer contains about 300 amino acids in DNA binding Rel District and I-κ B-binding domain. NF-κ B/Rel now known family members, including RelA (p65), RelB, c-Rel, v-Rel, p50, p52, Dorsal, Dif, and Relish, etc.. Form of NF-κ B activation by the p50 subunit and p65 subunits formed heterodimers, in a variety of transcription process play a key role. In static cells, p50/p65 dimer in plasma with the I-κ Bα , I-κ Bβ and I-κ Bγ combined in order to prevent their entry into the nucleus with DNA. Rel family have been involved in the occurrence of cancer was confirmed, but also a member of the NF-κ B activation, and different forms of Rel members may have different target gene activation. NF-κ B-specific DNA recognition element 5’-GGGRNYYYCC-3 ‘(R non-specific purine, Y are non-specific pyrimidine, N for nucleotides). 2.9