Of topiramate and valproate on bone metabolism in children with epilepsy.docVIP

 PAGE \* MERGEFORMAT 4 Of topiramate and valproate on bone metabolism in children with epilepsy Author: Wang Kai-Xuan Wei Yi Xu Minhui Su Kim Yun-guang ZHAO Shi-Yong Mei package [Keywords:] Topiramate Valproate bone metabolism in epilepsy Epilepsy is one of the common diseases of the nervous system in children, the incidence is about 7 ‰ [1], long-term use of antiepileptic drugs may affect bone metabolism and bone growth and development, the process is slow because it took place, clinical manifestations, malaise, and very rarely pay attention to . Topiramate as a novel antiepileptic drug, its coverage of bone metabolism less at home and abroad. By taking a separate study of topiramate and valproate in epileptic children taking separate bone mineral density and serum alkaline phosphatase, calcium, phosphorus changes, and discusses the anti-epileptic drugs on bone metabolism in children with epilepsy. A clinical data 1.1 The object of study (1) case group: 77 cases were from January 2004 to December 2007 in children with epilepsy in this region. Meet the diagnostic criteria for epilepsy at the Epilepsy International League Against Epilepsy classification of the diagnostic criteria of idiopathic epilepsy. Excluded: children with mental illness, other neurological and living areas difference is greater, other diseases that affect bone metabolism (bone hypoplasia, osteogenesis imperfecta, rickets, thyroid disease, parathyroid dysfunction, gigantism, severe liver and kidney disorders, etc. ), taking other drugs affecting bone metabolism (such as the adrenal cortex hormones, sex hormones). Grouped according to the drugs, which alone of topiramate (TPM) group of 32 patients (18 males and 14 females), age 5 ~ 16 (10.1 ± 2.4) years of age, height (137.0 ± 11.8) cm, body weight (30.8 ± 7.7 ) kg, TPM initial dose of 0.5 ~ 1mg/kg * d, every 1-2 weeks to increase 0.5 ~ 1mg/kg, maintenance dose of 3 ~ 5mg/kg * d; alone valproate (VPA) group of 45 patients ( male 2