Olive pontine cerebellar atrophy and clinical observation of 23 cases.doc

 PAGE \* MERGEFORMAT 7 Olive pontine cerebellar atrophy and clinical observation of 23 cases [Keywords:] olive CT MRI pontine cerebellar atrophy Olive pontine cerebellar atrophy (OPCA) is a group of genetic predisposition and more parts of the central nervous system degeneration and atrophy of diseases, the main clinical manifestations of cerebellar ataxia, some accompanied by autonomic and extrapyramidal symptoms and other nervous system signs and symptoms. The onset forms, clinical easier to ignore. now in our hospital from 2000 to 2008 23 patients were treated OPCA patients diagnosed with clinical data were analyzed and reported as follows. 1 Clinical data 1.1 General Information The group of 23 patients, 18 males and 5 females. Aged 40 to 67 years, mean 54 years. Have a family history in 1 case, three generations of four. OPCA in 23 patients were retrospectively analyzed patients, telephone, or interview follow-up prognosis. 1.2 Clinical manifestations 1.2.1 cerebellar symptoms were 23 cases of cerebellar ataxia, 20 patients (86%) as the first symptom of unsteadiness; 17 cases (74%) after six months to two years, staggered gait; 3 (13% ) to slurred speech, dizziness onset, followed by ataxia. clinical signs are Romberg’s sign open eyes closed eyes standing firm, referring to nose test, rotation movement, with the knee-shin test clumsy inaccurate test positive rebound . 1.2.2 extrapyramidal symptoms in 15 cases (65%) showed slow, intention tremor, increased muscle tone. 1.2.3 Symptoms of pyramidal tract involvement in 10 cases (43%) had signs of pyramidal tract damage, manifested as tendon hyperreflexia, Babinski’s sign positive. 1.2.4 brainstem symptoms in 5 cases (22%) had dysphagia, dysarthria, drinking water, cough, gag reflex slow or disappear. 1.2.5 autonomic nervous symptoms in 14 cases (61%) had urinary frequency, urinary urgency, urinary incontinence; 6 cases (26%) had impotence; 3 (13%) associated with o