On the cerebral ischemic injury and oxidative stress antagonistic effect of Chinese medicine research.docVIP

 PAGE \* MERGEFORMAT 18 On the cerebral ischemic injury and oxidative stress antagonistic effect of Chinese medicine research Author: Chun-Xia Zhang HU Li-min Liu Ping Guo Kang source Paper Keywords: oxidative stress; cerebrovascular disease: free radicals Abstract: Oxidative stress (oxidative stress, 0S) ischemic cerebrovascular disease an important pathological reaction. Ischemic brain injury, reactive oxygen free radicals (oxygenflee radical, OFR) to increase, by way of necrosis or apoptosis caused by cell death, but also mediated by mitochondrial every track, nuclear transcription factor-signal transduction indirectly lead to apoptosis. In recent years, anti-oxidative stress the role of traditional Chinese medicine a growing emphasis on research in this area is increasingly in-depth. Cerebrovascular disease is harmful to human life and health, common diseases and frequently-occurring disease of mankind, one of the three major causes of death. With the aging of today??s society, the constant increase in the incidence of cerebral blood vessels in the United Nations World Health Organization survey of 57 countries died of cerebrovascular disease accounted for 11.3%, of which 40 countries accounted for cerebrovascular disease cause of death of the former three, while the ischemic cerebrovascular disease account for a large proportion. Ischemic brain injury in the pathological process is a complex pathogenesis involving the brain energy metabolism disorder, excitatory amino acid toxicity, free radical damage, inflammation and many other links. In recent years, the theory of oxidative stress in ischemic cerebrovascular disease in the role of a concern. Therefore, the Study of oxidative stress in ischemic cerebrovascular disease role, to clarify its mechanism, regulation mechanisms, clinical efficacy in finding better drugs to take effective preventive and control measures is of great significance. 1. Oxidative stress Pa