On the fat-regulating genes - UCP3 Genes.docVIP

 PAGE \* MERGEFORMAT 18 On the fat-regulating genes - UCP3 Genes Author: Cang mula Yang Tao Peng Dawa Drolma Business Paper Keywords UCP3; positioning; function; expression regulation; polymorphism Abstract UCP3 mitochondrial carrier protein gene is an important member of the family, is a candidate gene for obesity. An overview of UCP3 gene molecular structure, chromosomal location, biological function, expression and regulation mechanism, and its application in human disease, fat metabolism, animal production and system development in such areas and its applications are summarized and prospects. UCP3 (uncoupling protein3, UCP3) is a candidate gene for obesity, mainly in skeletal muscle mitochondrial membrane, ADP-mediated oxidation process and the process of uncoupling phosphorylation, so that the energy stored as not to ATP, but in the form of heat release. In 1997, Boss, etc. found in the brown adipose tissue UCP3 protein, belonging to mitochondrial carrier protein family, is located QTL the obese gene locus [1]. In this paper, at home and abroad on the UCP3 gene in molecular structure, chromosomal location, expression and regulation mechanism and the application of the latest research progress in a relatively comprehensive summary and discussion with a view to further study of UCP3 gene provide a reference. 1UCP3 Gene Mapping and Molecular Structure The study found that pig UCP3 gene located at 9P21-P24, there are six exons, open reading frame (Open reading f rame, ORF) of 936bp, encoding UCP3 protein contains 311 amino acids, and has six transmembrane functional domain and a purine nucleotide-binding domain, closely linked with the UCP2, UCP2 expression than the more extensive. Human UCP3 gene is located in 11q13, abundantly expressed in skeletal muscle, brown and white adipose tissue also has to express, and UCP2 uncoupling protein family belong to L and 73% homology, the two closely linked, separated by 75 ~ 150bp , UCP3 gene length 8.5Kb, at lea