On the high-frequency electrical stimulation of the subthalamic nucleus for Parkinson#39;s disease mechanism of Progress.docVIP

 PAGE \* MERGEFORMAT 11 On the high-frequency electrical stimulation of the subthalamic nucleus for Parkinson#39;s disease mechanism of Progress [Paper Keywords] Parkinson’s; subthalamic nucleus; high-frequency electrical stimulation [Abstract] Parkinson’s disease (Parkinson Disease, PD) is a kind of occurred in middle-aged period, tremor, muscle rigidity, exercise less, abnormal posture as the main characteristics of the sexual nervous system degenerative diseases. The current surgical treatment mainly stereotactic surgery and damage to the subthalamic nucleus high-frequency electrical stimulation. Stereotactic surgery is the most widely used damage the traditional surgical method, while it can improve PD motor symptoms but it is based on the cost of damaged nuclei. As people of the etiology and pathogenesis of PD study in-depth, the importance of the subthalamic nucleus has been valued by a growing number of scholars, with many of the basal ganglia nuclei have a wide range of nerve fiber link, called basal ganglia activity power “source.” In the PD animal testing and clinical treatment of PD patients, the high-frequency electrical stimulation of the subthalamic nucleus have achieved a satisfactory efficacy, but its mechanism is still a problem for the medical profession, this article on the research progress in recent years, a brief Overview. The subthalamic nucleus is the basal ganglia neural circuitry in a cross-node, which came in the adjustment of the basal ganglia control motor behavior information and played a certain role in the integration of its activities, change in the pathophysiologic mechanism of PD played a key role in Therefore, in-depth understanding of the role of the subthalamic nucleus contribute to understanding the pathogenesis of PD, while the study of new therapeutic approaches provide a theoretical basis. 1 subthalamic nucleus in Parkinson’s disease pathogenesis Basal ganglia - thalamus - corte