On the mechanism of fatigue in skeletal muscle cells.docVIP

 PAGE \* MERGEFORMAT 9 On the mechanism of fatigue in skeletal muscle cells [Abstract] This paper discusses the two forms of fatigue: one is constantly to the skeletal muscle to continually produce high-frequency stimulation, and the other one is generated due to repeated tetanic stimulation. Analysis of muscle fiber tension leading to possible reasons for the decline. [Keywords:] stimulation; fatigue; pulse; T tubule Of animal movement in skeletal muscle power plant, its work can be precisely controlled by the nervous system, skeletal muscle cells can be chemical energy into mechanical energy, it is vividly called ‘engine’. But it is the engine compared to the defect is extended with the movement, its speed and strength aspects of performance variation, the output power decrease, which is produced a so-called ‘fatigue’. In principle, fatigue may occur from the central command system to skeletal muscle fiber cross-bridge movement in any one process or location. Specifically includes the following processes or location: motor neuron conduction of action potentials; nerve-muscle contact point; action potential of the muscle cell surface membrane depolarization, sodium - potassium channel activation, causing action potential; action potentials along the muscle membrane surface spread and into the transverse tubule system; transverse tubule system, action potential caused by the release of stored Ca2 (into the muscle slurry); due to Ca2 reach the muscle protein C, causing a primary muscle protein actin activity from the movement; cross-bridge campaign began, muscle cell contraction; ATP dependent Ca2 continuous flow pump to return to the SR, leading to Ca2 troponin C from the Department removal of cross-bridge movement stops, muscle relaxation. Studies of laboratory animals used in fatigue is generally mice, Xenopus laevis is or mammals, take them to a single skeletal muscle fibers. Such measured results comparison purposes, is also beneficial to explain the