Paracetamol and more storage library implant chamber Preparation and in vitro release performance test.docVIP

 PAGE \* MERGEFORMAT 14 Paracetamol and more storage library implant chamber Preparation and in vitro release performance test Of: Li Weifeng, Wang Xiaopeng, cattle Hillsborough, Stella Lau, Van’t [Abstract] Objective poly lactic glycolic acid (PLGA) was prepared to release paracetamol-type storage library system, to study the in vitro release properties. Methods Preparation of paracetamol MEMS multi-chamber storage library type implants, high performance liquid chromatography of drug release performance. this experiment C18 column using methanol water (15:85) as mobile phase, detection wavelength 215nm, flow rate of 0.8mL/min. the result vector of different shapes, in vitro drug significant difference of release rate, the foreign agent within a sustained release implant hexagon curve of paracetamol found Higuchi equation. Conclusions of paracetamol-type multi-chamber storage library implant process is feasible, vector shape of the cavity on in vitro drug release rate of a more significant impact. [Keywords:] paracetamol, polylactic acid glycolic acid, multi-cavity implant, in vitro release ABSTRACT: Objective To prepare Paracetamol (APP) multiloculated implant loaded with poly lactide co glycolide acid (PLGA) and to study the drug release profile in vitro. Methods APP multiloculated implant was fabricated by micro electro mechanical system (MEMS), and high performance liquid chromato graphy (HPLC) measurement was used to investigate in vitro drug release profile. HPLC analysis was carried out by employing C18 column and a mixture of methanol water (15:85) as mobile phase. The detection wavelength was 215nm and flow rate was 0.8 mL / min. Results With different multiloculated shape, the rate of the drug release in vitro was varied significantly. Moreover, the releasing of APP multiloculated implant with ecto tetragonum ento hexagon in vitro conformed to Higuchi equation. Conclusion The technology of the preparations is feasible , and the structural