Patients with chronic hepatitis C antibody and anti-anticardiolipin 2significance of glycoproteinantibodies.doc

 PAGE \* MERGEFORMAT 8 Patients with chronic hepatitis C antibody and anti-anticardiolipin 2significance of glycoproteinantibodies [Abstract] Objective To investigate the anti-cardiolipin antibodies (ACA) and anti-2-glycoprotein (2 GPI) antibodies and chronic hepatitis C (HCV thromboembolism in patients with symptoms of a merger. Methods by enzyme-linked immunosorbent assay (ELISA) semi- Quantitative Determination of 61 patients with HCV patients and 30 healthy controls serum anti-cardiolipin antibodies (ACA) and anti-2-glycoprotein I antibodies. The results of serum anti-HCV and anti-2 GPI ACA positive rates were 24.6%, 16.4%, respectively, significantly higher than the control group (P lt;0.05 or lt;0.01, HCV with anti-thrombosis group and anti-2 GPI ACA positive rates were 93.3% and 66.7%, respectively, significantly higher than HCV non-thrombus group (P lt;0.01. Conclusion Anti 2 GPI antibodies and HCV is not only closely related to merger and specific symptoms of thromboembolism higher than the ACA, may be symptoms of HCV merge an important indicator of thrombosis. [Keywords:] anti-cardiolipin antibodies, anti-2-glycoprotein antibodies, chronic hepatitis C, thromboembolism Chronic hepatitis C (HCV patients with immune disorders are very common, can occur in a variety of serum autoantibodies. Anticardiolipin antibodies (anti cardiolipin antibody, ACA is based on cardiolipin as target antigen of autoantibodies, can lead to unknown reasons the body vein thrombosis. ACA, anti-2-glycoprotein (2glycoprotein, 2 GPI antibody as a autoantibodies also common in patients with chronic hepatitis C in serum. The author of serum HCV by detecting ACA and anti-2 GPI antibody levels, aims to HCV is in its relationship with thromboembolic symptoms in combination. Materials and Methods 1. The object 61 patients with chronic hepatitis C, were from our hospital in February 2007 hospitalized patients 11 months, including 34 males and 27 females, aged 18 to 86 y