Perinatal Research venous thromboembolism.doc

 PAGE \* MERGEFORMAT 14 Perinatal Research venous thromboembolism [Keywords:] vein thrombosis; perinatal Venous thromboembolism (venous thromboembolism, VTE) including deep vein thrombosis (deep venous thrombosis, DVT) and pulmonary embolism (pulmonary embolism, PE), is the mother during pregnancy and postpartum life-threatening major complications. PE can often within minutes of death, perinatal death among women is one of the main. 1 Epidemiology European and American countries, a large number of epidemiological and genetic epidemiological studies confirmed that perinatal high incidence of DVT, to 0.1%, PE incidence rate of about 0.01% ~ 0.04%, while the DVT is a risk of PE are the most important factors, perinatal PE is the main reason of maternal deaths [1]. New research shows that the domestic [2], perinatal DVT incidence of 0.052%, PE incidence rate of 0.003%, DVT perinatal mortality rate is 0.002%, both lower than abroad. DVT if treated soon enough, 24% occurred PE, of which about 13% of maternal deaths; if the provision of appropriate anticoagulant therapy, PE incidence can be reduced to 4.5%, maternal mortality can be reduced to less than 1% [ 3]. VTE is currently severely affected by perinatal maternal and perinatal mortality in children, so perinatal epidemiological studies of VTE have important significance. 2 Etiology and pathogenesis of At present, the academic community has been recognized as causes of VTE occurred in Virchow proposed that three major causes of thrombosis: blood stagnation, hypercoagulability and vascular wall damage. The data from abroad shows that the major perinatal risk factors for VTE included: age ≥ 35 years of age, obesity, body mass index increased rapidly, thrombosis history, post-natal oral estrogen withdrawal milk, post-natal oral contraceptives, bed time for a long time, chronic diseases, cesarean section , cardiovascular disease, premature birth, multiple pregnancy, lupus anticoagulant and anticardiolipin