Perioperative mild hypothermia treatment of severe traumatic brain injury clinical observation.doc

 PAGE \* MERGEFORMAT 3 Perioperative mild hypothermia treatment of severe traumatic brain injury clinical observation [Abstract] Objective of the severe brain injury in patients undergoing treatment for mild hypothermia on the efficacy of observation, of perioperative mild hypothermia therapy on brain protective effect in these patients and their clinical significance. Methods 56 patients with severe traumatic brain injury patients (GCS score 3 to 8 points) were randomly divided into mild hypothermia treatment group and control group. Of mild hypothermia in patients after injury, into the operating room line of mild hypothermia, brain temperature control at 32 ℃ ~ 35 ℃ ; control group were treated at room temperature. Two groups were observed during the treatment of patients with carotid artery and jugular venous blood gas, electrolyte changes, intracranial pressure (ICP) and brain tissue oxygen partial pressure (PbtO2) and blood pressure, heart rate, respiration and other vital signs. The prognosis of two groups of patients to conduct GOS score. Results hypothermia patients of cerebral extraction of oxygen (CEO2) and cerebral arterio-venous oxygen pressure difference (A-VDO2) were significantly lower than the control group, the differences were statistically significant (t = = 14.89,10.19, P all amp;quot;.05 ); mild hypothermia treatment group of patients with high ICP were significantly lower than 3,7 d after the operation the control group, the differences were statistically significant (t = = 2.79,6.89, P all amp;quot;0.05); mild hypothermia treatment group of patients PbtO2 Yu since 3d was significantly higher postoperative patients, the differences were statistically significant (t = = 4.11,6.90, P all amp;quot;0.05); by the GOS outcome score, mild hypothermia in patients treated group recovered well 67.86% (19 / 28) and the control group 39.28% (11/28), the difference was statistically significant (χ 2 = 3.42, P amp;lt;0.05); mortality rate was 14.29%