pH-sensitive dextran hydrogels GMA-Preparation and in vitro release study.doc

 PAGE \* MERGEFORMAT 7 pH-sensitive dextran hydrogels GMA-Preparation and in vitro release study Authors: WU, Zhen-Xi Zhang, Dao, Bo Ren, Sudan [Keywords:] drug release Preparation and in vitro evaluation of pH sensitive GMAdextran hydrogels [Abstract] AIM: To prepare the biodegradable pHsensitive hydrogels for controlled drug delivery and to study its intelligent drugrelease characteristics. METHODS: Hydrogels were obtained by radical copolymerization of aqueous solution of glycidyl methacrylate derivatived dextran (GMAdex) with acrylic acid (AAc) using ammonium peroxydisulfate (APS) and N, N, N, Ntetramethylethylenediamine (TEMED) as an initiation system. The degree of GMA substitution (DS) was determined by 1HNMR. The hydrogels were subjected to equilibrium swelling studies in enzymefree simulated gastric and intestinal fluids (SGF and SIF). The release profiles of Pingyangmycin (PYM) entrapped hydrogels in vitro were established in enzymefree SGF and SIF. RESULTS: The DS of GMA was 10.5 and the swelling studies clearly indicated that these hydrogels were more swollen in SIF than those in SGF . The release of PYM from the hydrogels was much faster in SIF. After 24 h, about 22% and 43% of the entrapped drug were released in SGF and SIF, respectively. CONCLUSION: The swelling and drug release of Poly (GMAdex / AAc ) hydrogels are strongly dependent on the pH value. [Keywords] dextran; acrylic acid; hydrogels; pHsensitive; swelling; drug release [Abstract] Objective: To study the system for the controlled release biodegradable pH-sensitive hydrogels preparation methods and intelligent release. Method: ammonium persulfate (APS) and tetramethylethylenediamine (TEMED) the initiator system, glycidyl methacrylate (GMA)-modified dextran (GMAdex) and acrylic acid (AAc) hydrogels prepared by radical copolymerization. GMAdex in the degree of GMA substitution (DS) determined by NMR. in the absence of enzymes in artificial gastric juice and artificial intestinal flu