Phosphate Ligustrazin Research on pharmacology and toxicology.docVIP

 PAGE \* MERGEFORMAT 13 Phosphate Ligustrazin Research on pharmacology and toxicology 【Abstract】 Objective To review the role of phosphate TMP and safety of the pharmacology and toxicology research methods. Methods According to the literature in recent years, introduced the relevant pharmaceutical characteristics of TMP phosphate, and phosphate Ligustrazin pharmacology, safety, experiment, experiments, pharmacokinetics aspects in detail. The results for phosphate Ligustrazine ischemic cerebrovascular diseases (such as cerebral insufficiency, cerebral thrombosis and cerebral embolism) has great clinical value. Conclusion phosphate Ligustrazin safe in clinical use, effective, and will demonstrate good clinical application prospect. Keywords: Ligustrazine Phosphate Injection; pharmacology; security; pharmacokinetics TMP phosphate injection is a sterile aqueous phosphate of TMP. Tetramethylpyrazine phosphate chemical name is 2,3,5,6  tetramethyl pyrazine phosphate monohydrate, with anti-platelet aggregation of reconciliation together, the expansion of small arteries, improve microcirculation, increase cerebral blood flow and blood circulation Huayu effect [1]. In recent years, the majority of scholars, the pharmacological effects of phosphate TMP conducted extensive research. Are summarized as follows: 1 Pharmacology 1.1 inhibit platelet aggregation in pathological conditions, many factors can cause platelet aggregation occurs, which can lead to microcirculatory disturbance. TMP can inhibit platelet aggregation, it can improve microcirculation and help cure the disease. TXB2 and 6  Keto  PGFla increase can promote platelet aggregation occurs. Application of TMP treatment, platelet aggregation, thromboxane B2 (TXB2), 6   keto prostaglandin Fla (6  Keto  PGFla) and other indicators were significantly decreased. In addition, the TMP can inhibit ADP, collagen and thrombin-induced platelet aggregation [2]. In rabbit p