Phthalate esters on male reproductive system toxicity.doc

 PAGE \* MERGEFORMAT 12 Phthalate esters on male reproductive system toxicity [Keywords:] phthalate esters; genitalia, male (male) sex; gene 0 Introduction Of phthalate esters on reproductive toxicity studies, began in the last century 80s. By nearly 20 a large number of studies, including animal and in vitro experiments confirmed that the reproductive toxicity of phthalate esters, and draw the corresponding conclusions, such as the dose - response relationship (the smallest dose had no effect on-NOAEL), toxic mechanism (anti-material role of the male hormone), as well as the influence of gene expression. while the role of gene expression studies, focusing mainly on 20th century, 90 years end date. This paper will conduct a review of related. A phthalic acid ester compounds of the male reproductive system toxicity of Research Phthalates (phthalate esters, PEs) are a class of fat-soluble synthetic organic compounds, mainly 2-ethylhexyl phthalate (DEHP), Di-phthalate esters (DBP), o-phthalic acid Butyl benzyl ester (BBP), is a global environmental contaminants are widely present in the air, water, soil and biological in vivo. this kind of compounds are closely related with our daily lives, through drinking water, eating, skin contact (cosmetics) and breathing into the human body, on human health effects of different degrees of harm. In the study of rodents found in PEs have carcinogenic, teratogenic, mutagenic role of [1], studies have shown that these compounds have anti-androgen effect , and such effect, however, did the classic anti-androgens are known to have a certain distinction, mainly in its or its metabolites are not with the androgen receptor (androgen receptor, AR) a direct activation or antagonism, thus that they may have estrogenic activity, which can lead to toxic effects of the male reproductive system. Currently abroad on PEs Compounds has been considerable attention from the initial toxicology studies, ecological surveys, to the current b