PIK3CA in cervical intraepithelial neoplasia and cervical squamous cell carcinoma.doc

 PAGE \* MERGEFORMAT 14 PIK3CA in cervical intraepithelial neoplasia and cervical squamous cell carcinoma Of: Comte survival, justice million increase, Jiang Yan more [Abstract] Objective To investigate the PIK3CA in cervical intraepithelial neoplasia and cervical squamous cell carcinoma and its clinical significance. Methods Immunohistochemistry was used to detect 10 cases of LSIL, 30HSIL, 50SCC PIK3CA protein in paraffin expression levels of groups were compared the difference and with the clinical pathological features. Results PIK3CA in LSIL and HSIL, the positive rate was 20% and 63.3%, the difference was significant (P = 0.044), PIK3CA in squamous cell carcinoma high expression, the positive rate was 76%, but clinical and pathological features of patients with no significant association. CONCLUSION PIK3CA in LSIL to HSIL in the transformation process, enhanced expression, PIK3CA expression of cervical cancer may be an early event during the formation, changes in the process of cervical cancer, PIK3CA in squamous cell carcinoma invasion and metastasis is not obvious. [Keywords:] PIK3CA cervical intraepithelial neoplasia cervical squamous cell carcinoma Abstract: Objective The study was designed to examine the clinicopathological significance of PIK3CA expression in squamous intraepithelial lesions (SIL and squamous cell carcinomas (SCC of the uterine cervix. Methods We assessed the expression of PIK3CA by immunohistochemistry in 10 LSIL, 30 HSIL, and 50 cervical SCC, and correlated these findings with various clinicopathological variables. Results PIK3CA was overexpressed in 20% of LSIL (2/10and 63.3% of HSIL (19/30. PIK3CA expression in HSIL was significantly higher than the expression in LSIL (P = 0.044 ). PIK3CA expression is highly prevalent in cervical carcinoma, with 76% of cervical SCC (38/50PIK3CA positive, but no significant associations were found between PIK3CA over-expression and clinicopathological variables. Conclusions PIK