- 1、本文档共15页,可阅读全部内容。
- 2、原创力文档(book118)网站文档一经付费(服务费),不意味着购买了该文档的版权,仅供个人/单位学习、研究之用,不得用于商业用途,未经授权,严禁复制、发行、汇编、翻译或者网络传播等,侵权必究。
- 3、本站所有内容均由合作方或网友上传,本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺!文档内容仅供研究参考,付费前请自行鉴别。如您付费,意味着您自己接受本站规则且自行承担风险,本站不退款、不进行额外附加服务;查看《如何避免下载的几个坑》。如果您已付费下载过本站文档,您可以点击 这里二次下载。
- 4、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等,请点击“版权申诉”(推荐),也可以打举报电话:400-050-0827(电话支持时间:9:00-18:30)。
查看更多
PNS in chronic renal ischemia renal interstitial fibrosis
PAGE \* MERGEFORMAT 15
PNS in chronic renal ischemia renal interstitial fibrosis
Of: Xieji Qing, Jin Jiansheng, pay with a double
[Abstract] Objective To observe the PNS (PNS) on chronic renal ischemia in rats. Methods Rats were randomly divided into sham operation group, model group and treatment group PNS. Established renal artery stenosis renal agenesis blood of rats, respectively, 7,28,45,60 days after modeling, rats were killed. interstitial renal morphological changes were detected by immunohistochemistry tubulointerstitial @ SMA expression at different time points , radioimmunoassay of serum IL 2 levels, ELISA detection of serum platelet-derived growth factor (PDGF) levels. Results The renal interstitial fibrosis, renal tubular epithelial cells and interstitial @ SMA expression and serum PDGF levels at each time point was significantly higher than sham operation group (P lt;0.01), PNS treatment group, these indicators at different time points significantly lower than model group (P lt;0.05 or P lt;0.01). model group, serum IL 2 content was significantly increased 7 d (P lt;0.01), then rapidly decreased to the level of the sham group, 45 d was significantly lower than the sham group (P lt;0.05). PNS treatment serum IL 2 content in the 7 d time low in the model group (P lt;0.05), the other time points no significant difference. Conclusion PNS may inhibit the renal phenotype of interstitial cells and reduce the levels of cytokines PDGF and IL 2 levels of early reduction and improvement of chronic renal agenesis blood of renal interstitial fibrosis.
[Keywords:] PNS; chronic disease; kidney; ischemia; interstitial cells; interleukin-2; platelet-derived growth factor; Actins
In recent years that the “chronic renal ischemia” is the first signal of renal fibrosis, as an independent factor in ischemic tubulointerstitial injury and even lead to renal interstitial fibrosis is more and more attention of scholars [12]. renal interstitial fibrosis in the
您可能关注的文档
- Pith decompression of femoral head allograft fibula transplantation in treatment of femoral head necrosis.doc
- Pit and fissure sealants in children age six shallow tooth caries efficacy of 3-year.doc
- Pituitary Clinical analysis of 45 cases of infertility patients.doc
- Pituitary stalk interruption syndrome Clinical features of.doc
- Pituitrin combined phentolamine treatment of bronchiectasis with massive hemoptysis.doc
- Pituitary tumor transforming gene and lung cancer.doc
- Pituitrin induced hyponatremia clinical analysis.doc
- Pituitary adenomas in the elderly Clinical and pathological analysis.doc
- Pituitrin treatment of hemoptysis in the observation and nursing care.doc
- Pity! Majority of the Chinese market are unable to find its own way!.doc
- 2024年中国钽材市场调查研究报告.docx
- 2024年中国不锈钢清洗车市场调查研究报告.docx
- 2024年中国分类垃圾箱市场调查研究报告.docx
- 2024年中国水气电磁阀市场调查研究报告.docx
- 2024年中国绿藻片市场调查研究报告.docx
- 2010-2023历年初中毕业升学考试(青海西宁卷)数学(带解析).docx
- 2010-2023历年福建厦门高一下学期质量检测地理卷.docx
- 2010-2023历年初中数学单元提优测试卷公式法(带解析).docx
- 2010-2023历年初中毕业升学考试(山东德州卷)化学(带解析).docx
- 2010-2023历年初中毕业升学考试(四川省泸州卷)化学(带解析).docx
文档评论(0)