PNS progress in the treatment of stroke mechanism.docVIP

 PAGE \* MERGEFORMAT 15 PNS progress in the treatment of stroke mechanism Of: Meng Lan Qing, Huang Ruiya, Wei Shige [Keywords:] stroke mechanism of PNS Stroke is one of the three diseases cause human death, a serious threat to human health, the high incidence of severe disability. A variety of mechanisms involved in brain injury after stroke, some traditional Chinese medicine with multiple therapeutic targets and for increasing people’s attention. PNS (panax notoginseng saponins, PNS is a famous traditional Chinese medicine Panax purified from the main pharmacological active ingredient, in recent years in research and treatment of stroke achieved encouraging results. This article PNS Stroke Advances mechanisms do a review to the clinical treatment of PNS to provide evidence of stroke. 1. Protect the blood-brain barrier, cerebral edema Stroke cerebral edema (brain edema leading to secondary brain injury factors, edema formation, the oppression of microcirculation, the hematoma surrounding tissue ischemia, which leads to increased intracranial pressure, gives rise to other brain regions or whole brain insufficiency , and its deadly consequences are the formation of life-threatening brain herniation. brain edema under the blood-brain barrier (BBB) #8203;#8203;whether the damage can be divided into vasogenic brain edema, cytotoxic cerebral edema and cerebral edema mixed. Jian-Hui Liu et al [1] by four vessel occlusion (4VO) model of complete cerebral ischemia in rats by intraperitoneal injection of PNS treatment, Evans blue protein determination BBB leakage to speculate the extent of damage, wet and dry weight determination of brain water content and found PNS groups treated with Evans blue content in animals, brain water content were significantly reduced, suggesting that PNS to improve the blood-brain barrier permeability and cerebral edema. cerebral edema related to the pathophysiology of major inflammatory response, complement activation, free ba