Polymyxin E sulfate aqueous solution surface tension and foam properties of.doc

 PAGE \* MERGEFORMAT 13 Polymyxin E sulfate aqueous solution surface tension and foam properties of Author: Luke Zhao-Liang Wu Yan-Li Zhao Jie Meng Liu, Guimin [Abstract] foam separation technique to explore the effective application of bio-separation process that separated the biological surface-active substances in the system, the performance of the importance of research. In this paper, sulfuric acid aqueous solution of polymyxin E system, study of polymyxin E sulfate concentration, miscellaneous proteins, inorganic ions, pH, and temperature on the sulfuric acid solution of polymyxin E surface tension and foam properties, for more than sulfuric acid Polymyxin E provide the basis for realization of foam separation. [Keywords:] sulfate, polymyxin E; surface tension; foam performance; foam separation ABSTRACT To investigate the easible application of biomolecule purification by the foam separation process. Polymyxin E sulfate solution was subjected as an example being applied to this process development. The influence determinants such as the concentration of polymyxin E sulfate, heterogeneous proteins which contained in the fermentation broth, inorganic ions, pH value and temperature, all were closely related to surface tension and foaming properties were studied. Experimental evidences were proposed for the successful application of foam separation process in the fields of antibiotics and biopharmaceuticals. KEY WORDS Polymyxin E sulfate; Surface tension; Foam properties; Foam flotation Foam separation technology is developing rapidly in recent 30 years, one of the new separation technology, which is mainly distributed in the use of gas bubbles in solution, by gas-liquid interface adsorption between the solute transfer or separation or enrichment to achieve the purpose of [1]. This method is simple equipment, separation, low cost, environmental pollution is small, in recent years, researchers attract more attention [2,3], in particular, is a bio-surfact