Polyoxometalate anti-tumor activity of Progress.doc

 PAGE \* MERGEFORMAT 33 Polyoxometalate anti-tumor activity of Progress Keywords: polyoxometalate; anti-tumor activity 0 Introduction Polyoxometalate is a class of multi-core network structure of the metal - oxygen clusters by transition metal ions (such as W Ⅵ, V Ⅴ, Mo Ⅵ, etc.) with oxygen to form a high degree of polymerization [1]. Anhydride containing a class called polyoxometalates with compounds containing two or more types of known heteropoly acid anhydride compounds. In 1826, Berzerius with ammonium and phosphate synthetase in its history a heteropoly compounds - 12 - molybdenum ammonium (NH4) 3 [PMo12O40]. 1864, Marignac synthesis of 12  tungsten acid H4 [SiW12O40] * nH2O, which really opened up a new era of multi-acid study [2]. After over a hundred years of development, polyoxometalates has been widely used in industrial catalysis, medicinal chemistry, materials chemistry and other fields. The application of chemistry in drug research is focused on anti-tumor, anti-virus, anti-AIDS, anti-clotting and anti-rheumatism, etc., this paper focused on an overview of the Department of tungsten, molybdenum polyoxometalate anti-tumor activity are reviewed. 1 Tungsten 1.1 General Department of heteropoly compounds of tungsten In 1971, Raynaud et al [3] In vitro experiments, was first found Heteropolyanion [SiW12O40] 4 - can inhibit MoMSV (Moroni’s murine sarcoma virus) in mouse embryonic fibroblasts in the transfers. In 1972, Michelon such reports of a cave-like structure of the antimony tungstate heteropoly compounds (NH4) 17Na [NaSb9W21O86] (code-named HPA-23) of the virus, DNA, RNA polymerase inhibited [4]. In 1974, Jasmin et al [5] found that HPA-23 can inhibit tumor induced by a virus, with HPA-23 treatment were infected with FLV (Friends of blood leukemia virus) in mice, can reduce the spleen weight, increase the average extension of the living time; also enables pre-planted MoMSV newborn mice a delayed