Polyoxyethylene castor oil with low concentrations of pgp substrate Rhodamine 123 permeability of intestinal mucosa.doc

 PAGE \* MERGEFORMAT 17 Polyoxyethylene castor oil with low concentrations of pgp substrate Rhodamine 123 permeability of intestinal mucosa [Abstract] Objective To observe the low concentration of polyoxyethylene castor oil on the regulation of intestinal p gp. Methods evaluated using in vitro diffusion cell method with rhodamine 123 (R123) by the jejunum, ileum and colon mucosa by secretion via the absorption of direction and the direction of The volume and permeability through (Papp, and different concentrations of surfactant on the R123 and fluorescein sodium (CF by the permeability of intestinal mucosa. R123 and the CF concentration in the receiving room by fluorescence spectrophotometry. R123 by the intestinal mucosa results through bad parts of existence, jejunum, ileum and colon of the order followed by reduction, R123 direction by the intestinal secretion was significantly higher than through the direction of the permeability of the absorption. low concentration The polyoxyethylene castor oil has increased by R123 direction by absorption, and reduce the permeability by the secretion of direction. But the test concentration of surfactants on the CF did not affect intestinal transit. Conclusions Low concentrations of polyoxyethylene castor-oil plant Sesame oil can inhibit the function of p gp and to improve by p gp-mediated drug absorption, these drugs are expected to improve the oral bioavailability. [Keywords:] p glycoprotein 123 fluorescence sodium polyoxyethylene castor oil diffusion cell through sexual Abstract: Objective to investigate the modulation of cremophor EL on the permeability characteristics of rhodamine123 (R123) across the different intestinal membranes. Methods The permeability (Papp) of R123 or fluorescein sodium (CF) via rat intestinal membranes at concentration of 5 g mL-1 was evaluated by an in vitro diffusion chamber system after the membranes were isolated from the intestine in rat, with or without the co administration of