Post-polio syndrome and anesthesia.doc

 PAGE \* MERGEFORMAT 6 Post-polio syndrome and anesthesia Post-polio syndrome (Post poliomyelitis syndrome, referred to as PPS) refers to the sequelae of poliomyelitis on the basis of a series of secondary pathological changes and symptoms, the incidence rate of 20% ~ 41%, and more at risk of polio 30 years after, that is, 40 to 60-year-old patients with sequelae of Polio. It is an academic on a new concept has emerged in recent years, some research advances are presented below. 1 History As early as 1875, Charcot reported that after years of suffering from acute polio re-emergence of muscular weakness. Dalakas and other such progressive muscle weakness and atrophy is named after poliomyelitis muscular atrophy. The 20th century, 80 years after the growing number of relevant reports, research deepening, later on known as post-polio syndrome. In the United States in 1987 was 1.6 million suffering from polio, there are 640,000 cases of post-polio syndrome have emerged. Work hard to continue to serve these patients, reduced mobility, can not even take care of themselves living. Patients in China are mainly distributed in the vast rural areas, working in the best of its ability to live occurred PPS rate than Europe, the Americas less. Symptoms, physical disorders is relatively light. The average age of patients in large cities due to the high physical fitness were more obese, PPS has been an increase in incidence in recent years. 2 Pathogenesis For the PPS pathogenesis number of assumptions. The most common is by polio virus attacks the motor unit of the excessive use and premature aging. Polio makes a large number of damaged neurons, loss of muscle, many muscle fibers in isolation without relying on, if the remaining part is still intact neighboring neurons, may, through its terminal axon collateral sprouting, so that each unit under the control of motor neurons increase in the number of muscle fibers. To be reduced from 100 to 1000, therefore, these residual