Pro-inflammatory and anti-inflammatory cytokines changes in the pathogenesis of hemorrhagic fever with renal syndrome in the role of.doc

 PAGE \* MERGEFORMAT 15 Pro-inflammatory and anti-inflammatory cytokines changes in the pathogenesis of hemorrhagic fever with renal syndrome in the role of [Abstract] Objective To study the hemorrhagic fever with renal syndrome pro-inflammatory and anti-inflammatory cytokines in the pathogenesis of role. Methods 35 patients (mild group of 19 cases, severe group of 16 patients) by stage of disease blood, ELISA and radioimmunoassay were used to detect ICAM-1, E-selectin, L-selectin, TGFβ -1, IFNγ , TNFα , IL-1β , IL-2, IL-4, IL-10 and other cytokines, and platelet and renal function over the same period. Results from heating up to a maximum period of urine, serum TNFα , IL-1β , IFNγ , IL-2, E-selectin, L-selectin and ICAM-1 on average higher than that of water, P amp;lt;0.05 ~ 0.01, while the IL - 4, TGFβ -1 significantly decreased serum IL-10 Despite the increase, but its rate of increase is lower than IFNγ , resulting in IFNγ /IL-10 ratio was significantly higher; TNFα , INFγ was consistent with the trend of BUN, but not with platelet opposite trend. Conclusion pathogenesis of hemorrhagic fever with renal syndrome, the existence of pro-inflammatory and anti-inflammatory cytokine imbalance, this uncontrolled inflammatory response is caused by capillary leakage and multiple organ dysfunction syndrome, the main mechanism. Reasonable and rehydration, appropriate use of immunomodulatory agents, as soon as possible to restore the balance of pro-inflammatory and anti-inflammatory, is expected to improve the prognosis of this disease. [Keywords:] hemorrhagic fever with renal syndrome; cell factor; E-selectin; L-selectin; transforming growth factor β -1 Changes of pro-and anti-inflammatory cytokines and their pathogenic significance in hemorrhagic fever with renal syndrome [Abstract] Objective The aim of this study is to investigate the changes of serum pro-and anti-inflammatory cytokines and their pathogenic significance in hemorrhagic fever with renal syn