Pro1019Pro leptin receptor gene polymorphism and hypertension in Wenzhou correlation between obesity.doc

 PAGE \* MERGEFORMAT 11 Pro1019Pro leptin receptor gene polymorphism and hypertension in Wenzhou correlation between obesity Of: Li Peizhen, Zhang Enyong, John Pan, Huang Road, Ying Jun, Zhang Hongqin, Societe Generale had [Abstract] Objective?: Learn Chinese Han population in Wenzhou leptin receptor (LEPR) Pro1019Pro genotype distribution of the gene polymorphism and hypertension with obesity. Methods: The polymerase chain reaction - restriction fragment length polymorphism Normality (PCR-RFLP) method for determination of the 381 cases of unrelated Chinese Han population in Wenzhou Pro1019Pro LEPR gene polymorphisms (normal control group, 111 cases, 148 cases of hypertension combined with obesity, hypertension, 122 cases of non-obese). Results: The obese hypertensive group LEPR gene Pro1019Pro the AA, GA and GG genotype frequencies were expressed 0.770,0.196, 0.034, G and A allele frequencies were 0.132 and 0.868; hypertension and genotype expression in non-obese group frequencies were 0.590,0.352 and 0.058, genotype G and A allele frequencies were 0.234 and 0.766; expression of the normal control group genotype frequencies were 0.514,0.405 and 0.081, G and A allele frequencies were 0.284 and 0.716; Pro1019Pro polymorphism frequency distribution of cases in the control group and differences between the groups was significant (P? lt;0.05), and the A allele frequency in obese patients with hypertension were significantly higher than non-obese group (P ? lt;0.05). Conclusion: LEPR gene Pro1019Pro Wenzhou Han population polymorphism and obesity-related hypertension. [Keywords:] leptin receptor; gene polymorphism; Hypertension; obesity; Wenzhou; Han Abstract:? Objective: To understand the genotype distribution of Pro1019Pro in Han population in Wenzhou area, and discuss its relation of hypertension patients to obesity. Methods:? The genotypes of Pro1019Pro variant in leptin receptor gene were determined with polymerase chain reaction-restriction fragmen