Progress in Brain Hemorrhage.docVIP

 PAGE \* MERGEFORMAT 3 Progress in Brain Hemorrhage [Keywords:] Cerebral Hemorrhage Cerebral hemorrhage incidence, mortality and disability are high, but so far there is no sure and effective treatment, while basic research is also far behind in the cerebral ischemia. Cerebral hemorrhage in recent years, have witnessed new progress in the study, combined with the domestic and the work of our center in recent years, a series of studies of cerebral hemorrhage are summarized below. First, an animal model of cerebral hemorrhage 60 years since the 20th century began, there are animal models of cerebral hemorrhage, type more, the use of animals are dogs, cats, pigs, rabbits, monkeys, apes, baboons, and rodents, etc. There are four main types of commonly used, different types have their own characteristics and applications. 1. Collagenase injection The method is three-dimensional positioning with micro-injection pump to the brain tissue into the VII collagenase solution, and guide brain hemorrhage. Collagenase is a metalloproteinase that can break down intercellular matrix and vascular basement membrane collagen, blood-brain barrier damage. After the blood vessel wall damage caused by bleeding, blood gradually gather around 4h integration into the hematoma bleeding area. Hematoma the size of the decision by the amount of collagenase. In 1990, first reported by Rosenberg and other injected 0.5U thrombin at 200 ~ 300 g SD rat caudate nucleus. 1998, Clark and other injection 0.07U collagenase in 26 ~ 36g of male Swiss albino mice made within the caudate nucleus of brain hemorrhage model. The model is simple, the resulting hemorrhage size, shape and location are basically consistent and repeatable. But take some time to produce bleeding, bleeding areas of diffuse oozing area, and clinical characteristics of spontaneous cerebral hemorrhage hematoma different. Chesney that the model is suitable for recovery of neurological function after intracerebral hemorrhage in th