Propylthiouracil induced neutropenia clinical analysis of 74 cases_0.docVIP

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2017-05-05 发布于浙江
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Propylthiouracil induced neutropenia clinical analysis of 74 cases_0.doc

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Propylthiouracil induced neutropenia clinical analysis of 74 cases_0

Propylthiouracil induced neutropenia clinical analysis of 74 cases [Abstract] Objective propylthiouracil (PTU induced neutropenia incidence, clinical manifestations and treatment strategies. Methods 74 patients with PTU induced neutropenia in clinical features and treatment were statistically analyzed. Results granulocyte Most occurred in the medication to reduce symptoms after 2 to 8 weeks, and with the PTU dose related. Most cases are dizziness, fatigue and clinical symptoms. All the patients continue to use the PTU, add services or subcutaneous rise Baiyao colony stimulating factor (G-CSF , granulocytes were normal, no case of agranulocytosis. Conclusion PTU starting dose should not exceed 300mg / d, with the first 1 to 2 months, WBC count should be closely observed, oral l Baiyao or G-CSF for injection white blood cell recovery is effective and can avoid the occurrence of agranulocytosis. [Keywords:] Hyperthyroidism agranulocytosis Hyperthyroidism (mainly medical treatment of hyperthyroidism with antithyroid drugs (ATD, the most commonly used of methimazole and propylthiouracil (PTU, the drug is causing major side effects or lack of neutropenia, he Ba azole has been a lot in this area reported in the literature, PTU induced agranulocytosis there are some reports, but the PTU induced neutropenia rarely reported. We collected hospital outpatient and inpatient cases of the past five years, 74 patients were treated with PTU induced grain cells to reduce symptoms in patients with clinical data were analyzed, and described the side effects of treatment strategies, which prevent the occurrence of agranulocytosis have important clinical significance. 1 Clinical data 1.1 The objects were 74 cases of outpatient and inpatient patients with hyperthyroidism, including 25 males and 49 females, aged 21 to 50 years old, average 32.8 years of age, duration of 1 to 14 months, an average of 4.2 months in all patients before the use of PTU white blood cell count we