Propolis on the D-gal induced Alzheimers antioxidant capacity of mice.docVIP

 PAGE \* MERGEFORMAT 10 Propolis on the D-gal induced Alzheimer’s antioxidant capacity of mice Analysis: High-jun 1, Zhang Yue Zhao Lei Su Xiaojie [Abstract] Objective To investigate propolis (EEP) of D-galactose induced senile dementia (AD) brain index and brain monoamine oxidase B (MAO-B), superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px). Methods 60 healthy Kunming mice were randomly divided into 6 groups, were normal group, model group, positive control group and high dose of propolis low three treatment groups. normal group fed conventional The remaining group of subcutaneous injection of D-galactose 100 mg kg-1 d-1, a total of 7 w, while modeling positive control group fed 50 mg kg-1 d-1 aniracetam capsule; treatment group 3 doses (300,150,75 mg kg-1 d-1) daily gavage propolis; model group was given equal volume of saline. The first 50 days mice were killed the brain, brain index and measured brain MAO-B, SOD, GSH-Px levels. Results of the brain the experimental group was significantly higher than the model group (P lt;0.05), SOD, GSH-Px activity was significantly higher than model group (P lt;0.01), MAO -B were significantly lower than the model (P lt;0.01), compared with the control group, similar to the index. Conclusion propolis can improve the cerebral index, enhance the antioxidant ability to inhibit MAO-B activity, thereby protecting brain cells against dementia. [Keywords:] propolis; D-galactose; senile dementia; cerebral index [Abstract] ObjectiveTo research of effects of propolis flavonoids on superoxide dismutase (SOD), monoamine oxidase-B (MAO-B), glutathione peroxidase (GSH-Px) in the Alzheimer disease (AD) mice’s brains and brain index.Methods60 mice were randomly divided into 6 groups.Mice in normal group were fed with conventional additives.The others group were administrated with D-galactose (100 mg kg-1 d-1) for successive 7 weeks.Simultaneously, the mice were given with 50 mg kg-1 d-1 aniracetam served