PTEN signaling pathways and progress of cancer research.docVIP

 PAGE \* MERGEFORMAT 19 PTEN signaling pathways and progress of cancer research Of: was this honesty, Linguan Ping, Zhou Ke-yuan [Abstract] PTEN is a tumor suppressor gene protein, has dual specificity phosphatase involved in the regulation of various signaling pathways. PTEN activity in the absence of a variety of human diseases, particularly in the tumors on the most common. In recent years, researchers have focused on the research PTEN transcriptional regulation of its own and not rely on kinase signaling pathways on PIP3. In this paper, PTEN and the signaling pathways associated with tumor were reviewed in the study. [Keywords:] tumor suppressor gene; PTEN; signal transduction; tumor; review literature PTEN is a tumor suppressor gene in 1997 by three research teams on the protein structure, gene mutations in cancer and gene regulation in areas such as study the expression of cloned, respectively, on chromosome 10, named for the loss of phosphatase homologous strain protein gene (phosphatase and tensin homologue deleted chromatosome 10, PTEN), multiple advanced cancer mutant gene (mutation in multiple advanced cancer, MMAC) and by TGF regulated and epithelial cell enriched phosphatase gene (TGF regulated and epithelial cell riched phosphatase 1, Tepl), are collectively referred to as PTEN gene [1-3]. cell signal transduction and cell communication within and outside of cells to the link between the control cells in almost all life activities. signal transduction occurrence will result in abnormal regulation of body disorders, affect cell growth, differentiation, metabolism and other diseases caused by the body functions. study found that the majority of signal transduction systems involved in protein is associated with oncogenes or tumor suppressor gene product, which abnormal expression of certain diseases, especially tumors, is closely related to the development. To date, numerous studies have confirmed: PTEN gene in a number of negative regu