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2017-05-05 发布于浙江
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Propofol infusion closed-loop system of Research and Development.doc

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Propofol infusion closed-loop system of Research and Development

Propofol infusion closed-loop system of Research and Development [Keywords:] the closed-loop infusion of propofol Closed-loop infusion system (closed-loop anaesthesia system, CLAN) is a nearly 15-year narcotic intravenous drug infusion system for the new concept, it is the traditional target-controlled infusion (target-controlled infusion, TCI) extension and development has become a new hotspot. CLAN is a kind of automatic control technology, from sensors, monitors, control computer module, the output implementation of the instrument, has a feedback signal control performance, which is open-loop systems with the fundamental difference. CLAN trying to medication infusion pumps, all kinds of information through the integration of efficacy feedback, and then control the dosage to achieve the ideal of medication purpose, as much as possible to reduce medication errors. Because of obvious advantages, the study of the delivery system is gradually increasing. 1 Background CLAN, formerly known as open-loop infusion system. The regulation of open-loop infusion system is the target plasma or target effect-site concentration, interference factors, the scope of hemodynamic fluctuations in large, easy to produce anesthesia too deep status. In the open-loop infusion system, the anesthesia doctor before and after treatment according to blood pressure, heart rate, EEG, electrocardiogram, tidal volume and the degree of muscle relaxation and other parameters by the computer to determine the outcome of treatment, thereby regulating dosage and speed. The regulation of CLAN is the best drug effect desired and the expected depth of anesthesia, in the closed-loop controlled infusion period, the feedback effects from the electroencephalogram, or EEG bispectral index (bispectral index, BIS) and other monitoring facilities are completed. CLAN study aims to improve the open-loop system for a number of shortcomings. 2 Clinical Applications 2.1 to BIS as a feedback signal in recent years