Progress in diagnosis and treatment of thalassemia.docVIP

 PAGE \* MERGEFORMAT 2 Progress in diagnosis and treatment of thalassemia Keywords:: Mediterranean anemia Progress in the diagnosis and treatment of thalassemia. Mediterranean Anemia (Thalassemia) is due to synthesis of globin chains are partially or completely inhibited, resulting in peptide chain synthesis imbalance caused by a group of hereditary hemolytic anemia. Domestic 1900s, some scholars advocate to translate it into thalassemia, and later another scientist raised the blood-globin anemia has not been agreed. Thalassemia can be divided into α -globin reduction or absence of synthetic peptides known as α -thalassemia and β globin chains synthesis, said the reduction or absence of β -thalassemia. A Mediterranean hemolytic anemia of the mechanism Mediterranean hemolytic anemia study found that a number of mechanisms leading to hemolysis in patients with thalassemia causes not only by the precipitation of excess globin chains cause membrane damage, oxidative damage, but also with the erythrocyte membrane skeleton abnormalities, red blood cell metabolism and red blood cell precursors, bone marrow generates invalid [7] relevant. 1.1 red blood cell red blood cell deformability infiltration tests confirm the patient’s red blood cell thalassemia is more rigid than normal red blood cells, red blood cell deformability weakened, easily destroyed in a loop. Abnormal membrane skeleton protein 1.2 The author Li β -thalassemia patients with red cell membrane for SDS gel electrophoresis and found to have excessive speetrin the increased levels of globulin [8]; further mRNA study [17] found that erythrocyte membrane α -thalassemia patients in - and β -contractile proteins in mRNA expression was significantly increased (P