Propolis flavonoids on cerebral ischemia-reperfusion injury in rats.docVIP

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Propolis flavonoids on cerebral ischemia-reperfusion injury in rats.doc

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Propolis flavonoids on cerebral ischemia-reperfusion injury in rats

Propolis flavonoids on cerebral ischemia-reperfusion injury in rats Of: Yuan Lijie Zhao Lei Zhang Yue Ling Chunying [Abstract] Objective propolis flavonoids on cerebral ischemia-reperfusion injury in rats. Methods SD rats were divided into sham operation group, model group and propolis high, medium and low dose group, middle cerebral artery occlusion (MCAO) production model, to detect the brain water content and infarct volume, brain tissue superoxide dismutase (SOD), peroxidase (CAT) activity and malondialdehyde (MDA) content. Results and Model group, three doses of propolis significantly reduced in brain water content (P lt;0.01), infarct volume was significantly reduced (P lt;0.01), SOD, CAT activity was significantly increased (P lt;0.01), MDA content was significantly lower ( P lt;0.01). Conclusion propolis has anti-free radical damage and protect the ischemic brain tissue. [Keywords:] propolis; cerebral ischemia; radical Ethanol extract of propolis (EEP) can improve the elasticity and permeability of blood vessels, relaxing blood vessels, blood vessel wall accumulation of clear material (1), with antioxidant, scavenging free radicals and ischemia-reperfusion injury protection effects (2). However, propolis flavonoids on ischemic brain damage is rarely reported a protective effect, this study rat model of ischemia-reperfusion injury by brain water content, infarct volume and brain tissue SOD (SOD), have dismutase (CAT) and malondialdehyde (MDA) to explore the determination of propolis cerebral ischemia-reperfusion injury prevention and control mechanism, prevention and treatment of cerebral ischemia and provide experimental basis. 1 Materials and methods 1.1 Materials SOD, CTA, MDA agent boxes were purchased from Nanjing Jiancheng Institute of biological agents and other reagents were analytical grade line; propolis flavonoids by the Department of Biochemistry, University of Chinese Medicine to provide. SD rats, male and female weight 250 30