Propolis flavonoids on learning and memory in aging mice.docVIP

Propolis flavonoids on learning and memory in aging mice Of: Wang Hao Zhang Yue Xu Xiaoyan Wang Xiaodan Gao Yongfeng Yun-Sheng Gao [Abstract] Objective To observe the propolis flavonoids on D galactose induced aging model the impact of learning and memory in mice and its mechanism were discussed. Methods Mice D galactose neck subcutaneous injection 42 d, prepared by aging model. Through the small rats on learning and memory ability and brain superoxide dismutase (SOD), glutathione peroxidase (GSH Px), malondialdehyde (MDA), lipofuscin (LF) in serum, the total evaluation of propolis anti-aging effect of flavonoids. The results compared with the control group, D galactose (150 g / kg, sc, 42 d reduced the ability of learning and memory in mice, brain tissue SOD, GSH Px activity decreased, MDA, LF content increased , and TFP 30 mg / kg, 60 mg / kg and 90 mg / kg dose group of three of these pathological changes with varying degrees of improvement. Conclusion TFP can improve the D galactose induced learning and memory dysfunction in aging mice The mechanism may be regulating antioxidant metabolism of free radicals. [Keywords:] propolis, flavonoids, learning and memory, lipofuscin, the aging Bee Propolis is collected from plants or tree trunks Bacillus honey, mixed with bees wax after maxillary gland secretion and processing of aromatic gel made of solid material. Propolis is rich in a variety of active ingredients with medicinal value, mainly flavonoids compounds, the study found propolis has antibacterial, anti-virus, anti-inflammatory, antitumor, immunomodulatory, scavenging free radicals and other biological activities (1,2). and propolis on learning and memory is rarely reported. our group pre- study found that ethanol extract of propolis on mice with a variety of learning and memory impairment has protective effects (3). On this basis, using the ultrasonic extraction of propolis flavonoids and observed its D galactose induced aging model mice memory f