Proprietary Chinese medicines containing mercury in cinnabar oral bioavailability and safety of_0.docVIP

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2017-05-05 发布于浙江
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Proprietary Chinese medicines containing mercury in cinnabar oral bioavailability and safety of_0.doc

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Proprietary Chinese medicines containing mercury in cinnabar oral bioavailability and safety of_0

Proprietary Chinese medicines containing mercury in cinnabar oral bioavailability and safety of Of: Qi Jiangning, Huguang Lin *, Jing Pang groups, Han Bin, Huang Qian [Abstract] Objective evaluation from the biological point of view the use of proprietary Chinese medicines containing mercury in cinnabar potential health risks. Flame atomic absorption spectrometry method (FAAS) determination of total mercury content of proprietary Chinese medicines containing cinnabar, in vitro digestion and dialysis method to simulate the human gastrointestinal digestion, hydride - atomic fluorescence spectrometry (HG-AFS) detection obtained with cinnabar mercury bioavailability of proprietary data. Results 6 Chinese medicine commonly used in artificial gastric juice containing the cinnabar mercury leaching rate of 0.14% ~ 1.96% within the small intestine phase mercury was accepted 8% 0.003 0.011 7%. Based on the half-life of mercury in the body and the accumulation of toxic amount of anti-derived mercury in Traditional Chinese Medicine with cinnabar safety threshold is per person per day 0.099 mg. Conclusion considering 6 commonly used Chinese patent medicines containing cinnabar mercury levels, dosage, frequency taken inferior, indicating that oral administration of medicine containing cinnabar mercury exposure caused by the security risk is low. [Keywords:] bioavailability; in vitro digestion dialysis; with cinnabar medicine; safety threshold; mercury Abstract: ObjectiveTo introduce mercury bioaccessibility for risk assessment of Chinese patent medicines containing cinnabar. MethodsTotal mercury from Chinese patent medicines containing cinnabar was determined by FAAS. In vitro digestion and dialysis method was adopted to simulate the conditions of gastric compartment and intestinal compartment and dialysate fractions were collected and quantified by the means of HG-AFS. ResultsIn the gastric compartment, the solubility of mercury from six common Chinese patent medic