Progress in diagnosis of renal fibrosis.docVIP

 PAGE \* MERGEFORMAT 5 Progress in diagnosis of renal fibrosis [Abstract] Renal fibrosis is the impact of various types of kidney disease, treatment and prognosis of one important factor to delay and block of renal fibrosis is the key to prevention and treatment of renal damage and is the current hot spot study of kidney disease at home and abroad. With the development of molecular biology techniques and application of a large number of studies have shown that TGF-β 1 is the start and termination of renal fibrosis, one of the key cytokines, PC Ⅲ , IV-C and renal fibrosis are also closely linked. Serological diagnosis of renal fibrosis will enable clinicians to dynamic observation of the degree of renal lesions, as well as time and accurately determine whether there is renal fibrosis and fibrosis contribute to rational treatment plan and accurate prognosis. [Keywords:] transforming growth factor; Ⅲ procollagen; Ⅳ collagen; renal fibrosis; diagnosis; PC Ⅲ ; IV-C; TGF-β 1 Renal fibrosis (including renal interstitial fibrosis and glomerular sclerosis) is a dynamic process of development, marked the irreversible kidney damage, affecting the various types of kidney disease treatment and prognosis of one of the factors [1]. Therefore, the delay and blocking renal fibrosis is the key to prevention and treatment of renal damage and is the current hot spot study of kidney disease at home and abroad. Ability to timely and accurate manner to determine whether there is renal fibrosis, will help clinicians to develop a reasonable treatment plan, and a more accurate prognosis. At present the clinical diagnosis of renal fibrosis in renal biopsy is still the main, but it has a traumatic, combined with other factors, it is difficult dynamic observation. Therefore, to find a way to more accurately reflect the degree of renal fibrosis of non-invasive inspection methods are precisely the difficulties faced by clinicians. In recent years, serological diagnosis of renal fibrosis