Propofol on lung ischemia reperfusion injury of apoptosis and related proteins.docVIP

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Propofol on lung ischemia reperfusion injury of apoptosis and related proteins.doc

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Propofol on lung ischemia reperfusion injury of apoptosis and related proteins

Propofol on lung ischemia reperfusion injury of apoptosis and related proteins Of: Lei Fu Xiaofei Wang Jianjun Liu Dong Zhao Song [Abstract] Objective To explore propofol on lung ischemia reperfusion injury (LIRI cell apoptosis and related proteins. Methods 42 male SD rats were randomly divided into 3 groups: sham operation group (S group), ischemia-reperfusion group (IR group, propofol group (P group. IR group, P group was established orthotopic model of lung ischemia-reperfusion (ischemia 1 h, reperfusion 3 h, P group in ischemic 30 min before intravenous infusion of propofol 5 mg kg-1 h-1. test taken immediately after the left lung specimens were detected by immunohistochemistry Bcl 2 and Bax protein expression, in situ detection of apoptosis ( TUNEL assay of lung epithelial cell apoptosis index (AI, while light microscope pathological changes of lung tissue. Results Compared with the S group, IR group increased apoptotic index, lung Bcl 2, Bax expression increased, Bcl 2/Bax ratio decreased significantly (P lt;0.05), compared with IR group, P group increased expression of Bcl 2 protein, Bax protein expression decreased and apoptosis index decreased (P lt;0.05), pathological changes in lung tissue under light microscope significantly lighter than the IR group. Conclusion Propofol has protective effects on rat LIRI, which may be expression and regulation of Bcl 2/Bax so as to reduce the lung cell apoptosis. [Keywords:] propofol, lung ischemia-reperfusion, apoptosis Ischemia-reperfusion injury in the lung (lung ischemia reperfusion injury, LIRI the process of apoptosis is an important cause of lung tissue damage one of the reasons (1.) Propofol (propofol are commonly used in clinical intravenous anesthetics, existing research that its LIRI have a protective effect (2), but the mechanism is not fully understood. This study LIRI rat model in vivo, LIRI propofol on lung cell apoptosis and related proteins, and to explore the possible mechanism. 1 Mat